Are beta blockers effective in preventing stroke-associated infections? - a systematic review and meta-analysis.

ABSTRACT:

Background

Excessive sympathoexcitation could lead to stroke associated infection. Inhibiting sympathetic excitation may reduce the infection risk after stroke. Thus, the present study aimed to determine the protective effect of beta blockers on stroke associated infection through systematic review and meta-analysis.

Methods

A systematic search of multiple databases were performed up to February 2022. The included studies required beta blockers therapy in stroke patients and assessed the incidence of stroke-associated infections. Outcomes of interest included infections, pneumonia, urinary tract infection and sepsis. Random-effects model was used for analysis. Heterogeneity was evaluated using I2 statistics and publication bias was evaluated by the funnel plot.

Result

SUBMITTER: Yang L 

PROVIDER: S-EPMC9186777 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature