Learning-related congruent and incongruent changes of excitation and inhibition in distinct cortical areas.

ABSTRACT: Excitatory and inhibitory neurons in diverse cortical regions are likely to contribute differentially to the transformation of sensory information into goal-directed motor plans. Here, we investigate the relative changes across mouse sensorimotor cortex in the activity of putative excitatory and inhibitory neurons-categorized as regular spiking (RS) or fast spiking (FS) according to their action potential (AP) waveform-comparing before and after learning of a whisker detection task with delayed licking as perceptual report. Surprisingly, we found that the whisker-evoked activity of RS versus FS neurons changed in opposite directions after learning in primary and secondary whisker motor cortices, while it changed similarly in primary and secondary orofacial motor cortices. Our results sugge

SUBMITTER: Esmaeili V 

PROVIDER: S-EPMC9187120 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature