Ontology highlight
ABSTRACT:
SUBMITTER: Shi Y
PROVIDER: S-EPMC9187228 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Shi Yingdong Y Lin Lin L Wang Chao C Zhu Jinwei J
Science advances 20220610 23
The mechanosensory stereocilia in hair cells are organized into rows of graded height, a property crucial for auditory perception. Gpsm2-Gαi-Whirlin-Myo15-Eps8 complex at tips of the tallest stereocilia is proposed to define hair bundle row identity, although the underlying mechanism remains elusive. Here, we find that Gpsm2 could undergo phase separation. Moreover, row 1-specific Gpsm2-Gαi complex significantly promotes the formation of the five-component tip complex density (5xTCD) condensates ...[more]