Discoidin Domain Receptor 2 Expression as Worse Prognostic Marker in Invasive Breast Cancer.

ABSTRACT: Discoidin domain receptor 2 (DDR2) is arising as a promising therapeutic target in breast carcinoma (BC). The ability of DDR2 to bind to collagen promotes protumoral responses in cancer cells that influence the tumor microenvironment (TME). Nonetheless, the interrelation between DDR2 expression and TME modulation during BC progression remains poorly known. For this reason, we aim to evaluate the correlation between intratumoral expression of DDR2 and the infiltration of the main TME cell populations, cancer-associated fibroblasts (CAFs), and tumor-associated macrophages (TAMs). First, collagen and DDR2 expression levels were analyzed in human invasive BC samples. Then, DDR2 status correlation with tumor aggressiveness and patient survival were retr

SUBMITTER: Romayor I 

PROVIDER: S-EPMC9187291 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature