Transcriptional competition shapes proteotoxic ER stress resolution.

ABSTRACT: Through dynamic activities of conserved master transcription factors (mTFs), the unfolded protein response (UPR) relieves proteostasis imbalance of the endoplasmic reticulum (ER), a condition known as ER stress^1,2. Because dysregulated UPR is lethal, the competence for fate changes of the UPR mTFs must be tightly controlled^3,4. However, the molecular mechanisms underlying regulatory dynamics of mTFs remain largely elusive. Here, we identified the abscisic acid-related regulator G-class bZIP TF2 (GBF2) and the cis-regulatory element G-box as regulatory components of the plant UPR led by the mTFs, bZIP28 and bZIP60. We demonstrate that, by competing with the mTFs at G-box, GBF2 represses UPR gene expression. Conversely, a gbf2 null mutation enhances UPR gene expression

SUBMITTER: Ko DK 

PROVIDER: S-EPMC9187302 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature