External Validation and Comparison of Clostridioides difficile Severity Scoring Systems.

ABSTRACT:

Background

Many models have been developed to predict severe outcomes from Clostridioides difficile infection (CDI). These models are usually developed at a single institution and largely are not externally validated. Our aim in this study was to validate previously published risk scores in a multicenter cohort of patients with CDI.

Methods

This was a retrospective study on 4 inpatient cohorts with CDI from 3 distinct sites: the universities of Michigan (2010-2012 and 2016), Chicago (2012), and Wisconsin (2012). The primary composite outcome was admission to an intensive care unit, colectomy, and/or death attributed to CDI within 30 days of positive testing. Both within each cohort and combined across all cohorts, published CDI severity scores were assessed and compared to e

SUBMITTER: Perry DA 

PROVIDER: S-EPMC9187324 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature