Spatial and Genomic Data to Characterize Endemic Typhoid Transmission.

ABSTRACT:

Background

Diverse environmental exposures and risk factors have been implicated in the transmission of Salmonella Typhi, but the dominant transmission pathways through the environment to susceptible humans remain unknown. Here, we use spatial, bacterial genomic, and hydrological data to refine our view of typhoid transmission in an endemic setting.

Methods

A total of 546 patients presenting to Queen Elizabeth Central Hospital in Blantyre, Malawi, with blood culture-confirmed typhoid fever between April 2015 and January 2017 were recruited to a cohort study. The households of a subset of these patients were geolocated, and 256 S. Typhi isolates were whole-genome sequenced. Pairwise single-nucleotide variant distances were incorporated into a geostatistical modeling framework

SUBMITTER: Gauld JS 

PROVIDER: S-EPMC9187325 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature