Advanced brain age in deployment-related traumatic brain injury: A LIMBIC-CENC neuroimaging study.

ABSTRACT:

Objective

To determine if history of mild traumatic brain injury (mTBI) is associated with advanced or accelerated brain aging among the United States (US) military Service Members and Veterans.

Methods

Eight hundred and twenty-two participants (mean age = 40.4 years, 714 male/108 female) underwent MRI sessions at eight sites across the US. Two hundred and one participants completed a follow-up scan between five months and four years later. Predicted brain ages were calculated using T1-weighted MRIs and then compared with chronological ages to generate an Age Deviation Score for cross-sectional analyses and an Interval Deviation Score for longitudinal analyses. Participants also completed a neuropsychological battery, including measures of both cognitive functioning and psyc

SUBMITTER: Dennis EL 

PROVIDER: S-EPMC9187589 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature