Biome-microbiome interactions in peri-implantitis: A pilot investigation.

ABSTRACT:

Background

Dental implants replace missing teeth in at least 100 million people, yet over one million implants fail every year due to peri-implantitis, a bacterially induced inflammatory disease. Our ability to treat peri-implantitis is hampered by a paucity of information on host-microbiome interactions that underlie the disease. Here, we present the first open-ended characterization of transcriptional events at the mucosal-microbial interface in the peri-implant crevice.

Methods

We simultaneously sequenced microbial and human mRNA from five pairs of healthy and diseased implants from the same patient and used graph theoretics to examine correlations between microbial and host gene expression in the peri-implant crevice.

Results

We identified a transcriptionally acti

SUBMITTER: Ganesan SM 

PROVIDER: S-EPMC9187590 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature