Identification and preliminary characterization of Plasmodium falciparum proteins secreted upon gamete formation.

ABSTRACT: Malaria long-term elimination depends on parasite transmission control. Plasmodium sexual stage maturation in the mosquito, including egress from the host erythrocyte, is one of the prime targets for transmission-blocking interventions. This work aims to identify candidate molecules potentially involved in gamete emergence from the host erythrocyte, as novel transmission blocking targets. We analyzed by quantitative mass spectrometry the proteins released/secreted by purified Plasmodium falciparum gametocytes upon induction of gametogenesis. The proteome obtained showed a good overlap (74%) with the one previously characterized in similar conditions from gametocytes of the rodent malaria parasite P. berghei. Four candidates were selected based on comparative analysis of their abundance val

SUBMITTER: Grasso F 

PROVIDER: S-EPMC9187623 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature