Iridium-catalyzed direct asymmetric reductive amination utilizing primary alkyl amines as the N-sources.

ABSTRACT: Direct asymmetric reductive amination is one of the most efficient methods for the construction of chiral amines, in which the scope of the applicable amine coupling partners remains a significant challenge. In this study we describe primary alkyl amines effectively serve as the N-sources in direct asymmetric reductive amination catalyzed by the iridium precursor and sterically tunable chiral phosphoramidite ligands. The density functional theory studies of the reaction mechanism imply the alkyl amine substrates serve as a ligand of iridium strengthened by a (N)H-O(P) hydrogen-bonding attraction, and the hydride addition occurs via an outer-sphere transition state, in which the Cl-H H-bonding plays an important role. Through this concise procedure, cinacalcet, tecalcet, fendiline and many

SUBMITTER: Wu Z 

PROVIDER: S-EPMC9187633 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature