Maximum entropy models provide functional connectivity estimates in neural networks.

ABSTRACT: Tools to estimate brain connectivity offer the potential to enhance our understanding of brain functioning. The behavior of neuronal networks, including functional connectivity and induced connectivity changes by external stimuli, can be studied using models of cultured neurons. Cultured neurons tend to be active in groups, and pairs of neurons are said to be functionally connected when their firing patterns show significant synchronicity. Methods to infer functional connections are often based on pair-wise cross-correlation between activity patterns of (small groups of) neurons. However, these methods are not very sensitive to detect inhibitory connections, and they were not designed for use during stimulation. Maximum Entropy (MaxEnt) models may provide a conceptually different method to

SUBMITTER: Lamberti M 

PROVIDER: S-EPMC9187636 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature