The association between chronic rhinosinusitis and proton pump inhibitor use: a nested case-control study using a health screening cohort.

ABSTRACT: This study aimed to evaluate the relationship between chronic rhinosinusitis (CRS) and proton pump inhibitor (PPI) use in a Korean population. The Korea National Health Insurance Service-National Sample Cohort was assessed from 2002 to 2013. Patients with CRS (n = 7194) and control participants (n = 28,776) were matched by random order at a 1:4 ratio for age, sex, income group, region of residence, and index date. We analyzed PPI use by patients with and without CRS. ICD-10 codes defined CRS, and claim codes defined previous PPI use. Conditional logistic regression analyzed the crude and adjusted odds ratios (ORs) with 95% confidence intervals (CI). Subgroup analyses were performed according to age and sex. There was a difference in PPI prescription history and prescription duration betwee

SUBMITTER: Choi HG 

PROVIDER: S-EPMC9187650 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature