Diagnosis of bipolar disorders and body mass index predict clustering based on similarities in cortical thickness-ENIGMA study in 2436 individuals.

ABSTRACT:

Aims

Rates of obesity have reached epidemic proportions, especially among people with psychiatric disorders. While the effects of obesity on the brain are of major interest in medicine, they remain markedly under-researched in psychiatry.

Methods

We obtained body mass index (BMI) and magnetic resonance imaging-derived regional cortical thickness, surface area from 836 bipolar disorders (BD) and 1600 control individuals from 14 sites within the ENIGMA-BD Working Group. We identified regionally specific profiles of cortical thickness using K-means clustering and studied clinical characteristics associated with individual cortical profiles.

Results

We detected two clusters based on similarities among participants in cortical thickness. The lower thickness cluster (46.8%

SUBMITTER: McWhinney SR 

PROVIDER: S-EPMC9187778 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature