Incidence and pattern of mycophenolate discontinuation associated with abnormal monitoring blood-test results: cohort study using data from the Clinical Practice Research Datalink Aurum.

ABSTRACT:

Objective

The aim was to examine the incidence and pattern of MMF discontinuation associated with abnormal monitoring blood-test results.

Methods

Data from people prescribed MMF for common inflammatory conditions in the Clinical Practice Research Datalink were used. Participants were followed from the first MMF prescription. The primary outcome was drug discontinuation with an associated abnormal blood-test result within 60 days. Secondary outcomes were drug discontinuation for any reason and discontinuation associated with severely abnormal blood-test results within 60 days. Multivariable Cox regression was used to examine factors associated with the primary outcome.

Results

The cohort included 992 participants (68.9% female, mean age 51.95 years, 47.1% with SLE) con

SUBMITTER: Nakafero G 

PROVIDER: S-EPMC9187914 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature