A novel inhalable quercetin-alginate nanogel as a promising therapy for acute lung injury.

ABSTRACT:

Background

Acute lung injury (ALI), a severe health-threatening disease, has a risk of causing chronic pulmonary fibrosis. Informative and powerful evidence suggests that inflammation and oxidative stress play a central role in the pathogenesis of ALI. Quercetin is well recognized for its excellent antioxidant and anti-inflammatory properties, which showed great potential for ALI treatment. However, the application of quercetin is often hindered by its low solubility and bioavailability. Therefore, to overcome these challenges, an inhalable quercetin-alginate nanogel (QU-Nanogel) was fabricated, and by this special "material-drug" structure, the solubility and bioavailability of quercetin were significantly enhanced, which could further increase the activity of quercetin and provid

SUBMITTER: Chen YB 

PROVIDER: S-EPMC9187928 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature