Optimizing drug inhibition of IgE-mediated anaphylaxis in mice.

ABSTRACT:

Background

Administering allergens in increasing doses can temporarily suppress IgE-mediated allergy and anaphylaxis by desensitizing mast cells and basophils; however, allergen administration during desensitization therapy can itself induce allergic responses. Several small molecule drugs and nutraceuticals have been used clinically and experimentally to suppress these allergic responses.

Objectives

This study sought to optimize drug inhibition of IgE-mediated anaphylaxis.

Methods

Several agents were tested individually and in combination for ability to suppress IgE-mediated anaphylaxis in conventional mice, FcεRIα-humanized mice, and reconstituted immunodeficient mice that have human mast cells and basophils. Hypothermia was the readout for anaphylaxis; therapeutic

SUBMITTER: Morris SC 

PROVIDER: S-EPMC9187951 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature