Phenotype, specificity and avidity of antitumour CD8⁺ T cells in melanoma.

ABSTRACT: Interactions between T cell receptors (TCRs) and their cognate tumour antigens are central to antitumour immune responses^1-3; however, the relationship between phenotypic characteristics and TCR properties is not well elucidated. Here we show, by linking the antigenic specificity of TCRs and the cellular phenotype of melanoma-infiltrating lymphocytes at single-cell resolution, that tumour specificity shapes the expression state of intratumoural CD8⁺ T cells. Non-tumour-reactive T cells were enriched for viral specificities and exhibited a non-exhausted memory phenotype, whereas melanoma-reactive lymphocytes predominantly displayed an exhausted state that encompassed diverse levels of differentiation but rarely acquired memory properties. These exhausted phenotypes wer

SUBMITTER: Oliveira G 

PROVIDER: S-EPMC9187974 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature