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Efficient synthesis of 1,3-naphtoxazine derivatives using reusable magnetic catalyst (GO-Fe₃O₄-Ti^(IV)): anticonvulsant evaluation and computational studies.

ABSTRACT: A series of 2-aryl/alkyl-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazines (S₁-S₁₁) were synthesized with an eco-friendly and recoverable nanocatalyst (GO-Fe₃O₄-Ti^(IV)) as an efficient magnetic composite. The new nanocatalyst was characterized by FT-IR, XRD and, EDS analysis. A conformable procedure, easy to work up and having a short reaction time with high yields are some advantages of this method. The new catalyst is also thermal-stable, reusable and, environment-friendly. The chemical structures of the synthesized 1,3-oxazine compounds were confirmed by comparing their melting points with those reported in literature. Then, the anticonvulsant activity of these compounds was assessed by the intraperitoneal pentylenetetrazole test (ipPTZ).

SUBMITTER: Khabnadideh S

PROVIDER: S-EPMC9188075 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Efficient synthesis of 1,3-naphtoxazine derivatives using reusable magnetic catalyst (GO-Fe₃O₄-Ti^(IV)): anticonvulsant evaluation and computational studies.

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Efficient synthesis of 1,3-naphtoxazine derivatives using reusable magnetic catalyst (GO-Fe3O4-Ti(IV)): anticonvulsant evaluation and computational studies.

OmicsDI is part of the ELIXIR infrastructure

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Efficient synthesis of 1,3-naphtoxazine derivatives using reusable magnetic catalyst (GO-Fe₃O₄-Ti^(IV)): anticonvulsant evaluation and computational studies.