Spliceosome inhibitor induces human hematopoietic progenitor cell reprogramming toward stemness.

ABSTRACT: The application of hematopoietic stem cells (HSCs) has been restricted due to limited cell sources and conventional methods for generating these cells by cell expansion and pluripotent stem cell differentiation have not been clinically achieved. Cell reprogramming technique provides a new hope for generating desirable cells. We previously reported that mouse differentiated hematopoietic cell reprogramming could be induced by small molecule compounds to generate hematopoietic stem/progenitor-like cells, whether the human hematopoietic cells could also be reprogrammed into HSCs by chemical compounds remains elusive. Here, we demonstrated for the first time that human committed hematopoietic progenitors could be reprogrammed into multipotent progenitors by spliceosome inhibitor. Combination o

SUBMITTER: Dong L 

PROVIDER: S-EPMC9188107 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature