GWYRE: A Resource for Mapping Variants onto Experimental and Modeled Structures of Human Protein Complexes.

ABSTRACT: Rapid progress in structural modeling of proteins and their interactions is powered by advances in knowledge-based methodologies along with better understanding of physical principles of protein structure and function. The pool of structural data for modeling of proteins and protein-protein complexes is constantly increasing due to the rapid growth of protein interaction databases and Protein Data Bank. The GWYRE (Genome Wide PhYRE) project capitalizes on these developments by advancing and applying new powerful modeling methodologies to structural modeling of protein-protein interactions and genetic variation. The methods integrate knowledge-based tertiary structure prediction using Phyre2 and quaternary structure prediction using template-based docking by a full-structure alignment proto

SUBMITTER: Malladi S 

PROVIDER: S-EPMC9188266 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature