Depolarizing Na_V and Hyperpolarizing K_V Channels Are Co-Trafficked in Sensory Neurons.

ABSTRACT: Neuronal excitability relies on coordinated action of functionally distinction channels. Voltage-gated sodium (Na_V) and potassium (K_V) channels have distinct but complementary roles in firing action potentials: Na_V channels provide depolarizing current while K_V channels provide hyperpolarizing current. Mutations and dysfunction of multiple Na_V and K_V channels underlie disorders of excitability, including pain and epilepsy. Modulating ion channel trafficking may offer a potential therapeutic strategy for these diseases. A fundamental question, however, is whether these channels with distinct functional roles are transported independently or packaged together in the same vesicles in sensory axons. We have used Optical Pulse-Ch

SUBMITTER: Higerd-Rusli GP 

PROVIDER: S-EPMC9188389 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature