SARS-CoV-2 infection- induced growth factors play differential roles in COVID-19 pathogenesis.

ABSTRACT:

Aims

Biologically active molecules cytokines and growth factors (GFs) are critical regulators of tissue injury/repair and emerge as key players in COVID-19 pathophysiology. However, specific disease stage of GFs dysregulation and, whether these GFs have associations with thromboembolism and tissue injury/repair in COVID-19 remain vague.

Main methods

GF profiling in hospitalized moderate (non-ICU) and critically ill (ICU) COVID-19 patients was performed through legendPlex assay.

Key findings

Investigation revealed profound elevation of VEGF, PDGFs, EGF, TGF-α, FGF-basic, and erythropoietin (EPO) in moderate cases and decline or trend of decline with disease advancement. We found strong positive correlations of plasma VEGF, PDGFs, and EPO with endothelial dysfunction ma

SUBMITTER: Gupta A 

PROVIDER: S-EPMC9188443 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature