Methylation-eQTL analysis in cancer research.

ABSTRACT:

Motivation

DNA methylation is a key epigenetic factor regulating gene expression. While promoter methylation has been well studied, recent publications have revealed that functionally important methylation also occurs in intergenic and distal regions, and varies across genes and tissue types. Given the growing importance of inter-platform integrative genomic analyses, there is an urgent need to develop methods to discover and characterize gene-level relationships between methylation and expression.

Results

We introduce a novel sequential penalized regression approach to identify methylation-expression quantitative trait loci (methyl-eQTLs), a term that we have coined to represent, for each gene and tissue type, a sparse set of CpG loci best explaining gene expression and acc

SUBMITTER: Liu Y 

PROVIDER: S-EPMC9188481 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature