Mechanical loading of cranial joints minimizes the craniofacial phenotype in Crouzon syndrome.

ABSTRACT: Children with syndromic forms of craniosynostosis undergo a plethora of surgical interventions to resolve the clinical features caused by the premature fusion of cranial sutures. While surgical correction is reliable, the need for repeated rounds of invasive treatment puts a heavy burden on the child and their family. This study explores a non-surgical alternative using mechanical loading of the cranial joints to prevent or delay craniofacial phenotypes associated with Crouzon syndrome. We treated Crouzon syndrome mice before the onset of craniosynostosis by cyclical mechanical loading of cranial joints using a custom designed set-up. Cranial loading applied to the frontal bone partially restores normal skull morphology, significantly reducing the typical brachycephalic appearance. This is

SUBMITTER: Moazen M 

PROVIDER: S-EPMC9188582 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature