Impact of the inversion time on regional brain perfusion estimation with clinical arterial spin labeling protocols.

ABSTRACT:

Objective

Evaluating the impact of the Inversion Time (TI) on regional perfusion estimation in a pediatric cohort using Arterial Spin Labeling (ASL).

Materials and methods

Pulsed ASL (PASL) was acquired at 3 T both at TI 1500 ms and 2020 ms from twelve MRI-negative patients (age range 9-17 years). A volume of interest (VOIs) and a voxel-wise approach were employed to evaluate subject-specific TI-dependent Cerebral Blood Flow (CBF) differences, and grey matter CBF Z-score differences. A visual evaluation was also performed.

Results

CBF was higher for TI 1500 ms in the proximal territories of the arteries (PTAs) (e.g. insular cortex and basal ganglia - P < 0.01 and P < 0.05 from the VOI analysis, respectively), and for TI 2020 ms in the distal territories of the arter

SUBMITTER: Sanvito F 

PROVIDER: S-EPMC9188620 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature