Effective psychological therapy for PTSD changes the dynamics of specific large-scale brain networks.

ABSTRACT: In posttraumatic stress disorder (PTSD), re-experiencing of the trauma is a hallmark symptom proposed to emerge from a de-contextualised trauma memory. Cognitive therapy for PTSD (CT-PTSD) addresses this de-contextualisation through different strategies. At the brain level, recent research suggests that the dynamics of specific large-scale brain networks play an essential role in both the healthy response to a threatening situation and the development of PTSD. However, very little is known about how these dynamics are altered in the disorder and rebalanced after treatment and successful recovery. Using a data-driven approach and fMRI, we detected recurring large-scale brain functional states with high temporal precision in a population of healthy trauma-exposed and PTSD participants before

SUBMITTER: Charquero-Ballester M 

PROVIDER: S-EPMC9188968 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature