Serum stratifin and presepsin as candidate biomarkers for early detection of COVID-19 disease progression.

ABSTRACT: The prognosis of patients with severe cases of COVID-19 is poor; thus, biomarkers for earlier prediction of COVID-19 progression are vital. We measured levels of five lung injury-related biomarkers, SP-D, KL-6, presepsin, kallistatin and stratifin, in serum samples collected serially during hospitalization from 31 patients with mild/moderate or severe/critical COVID-19 pneumonia, and their predictive performances were compared. Like the previously reported presepsin, a new biomarker candidate, stratifin, was significantly elevated with the onset of severe or critical symptoms in COVID-19 patients and decreased with symptom improvement. Notably, changes in stratifin and presepsin levels were distinctly earlier than those in SP-D, KL-6 and even SpO₂/FiO₂ values. Further

SUBMITTER: Arakawa N 

PROVIDER: S-EPMC9188980 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature