In Vivo Absolute Metabolite Quantification Using a Multiplexed ERETIC-RX Array Coil for Whole-Brain MR Spectroscopic Imaging.

ABSTRACT:

Background

Absolute quantification of metabolites in MR spectroscopic imaging (MRSI) requires a stable reference signal of known concentration. The Electronic REference To access In vivo Concentrations (ERETIC) has shown great promise but has not been applied in patients and 3D MRSI. ERETIC hardware has not been integrated with receive arrays due to technical challenges, such as coil combination and unwanted coupling between multiple ERETIC and receive channels, for which we developed mitigation strategies.

Purpose

To develop absolute quantification for whole-brain MRSI in glioma patients.

Study type

Prospective.

Population

Five healthy volunteers and three patients with isocitrate dehydrogenase mutant glioma (27% female). Calibration and coil loading phantoms.

SUBMITTER: Thapa B 

PROVIDER: S-EPMC9189023 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature