Distinct brain structural-functional network topological coupling explains different outcomes in tinnitus patients treated with sound therapy.

ABSTRACT: Topological properties, which serve as the core of the neural network, and their couplings can reflect different therapeutic effects in tinnitus patients. We hypothesized that tinnitus patients with different outcomes after sound therapy (narrowband noise) would have distinct brain network topological alterations. Diffusion tensor imaging and resting-state functional magnetic resonance imaging (fMRI) were prospectively performed in 60 patients with idiopathic tinnitus and 57 healthy controls (HCs). Graph-theoretical network analyses of structural connectivity (SC), functional connectivity (FC), and SC and FC coupling were performed. Associations between clinical performance and graph-theoretical features were also analyzed. Treatment was effective (effective group; EG) in 28 patients and i

SUBMITTER: Chen Q 

PROVIDER: S-EPMC9189078 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature