The genes controlling normal function of citrate and spermine secretion are lost in aggressive prostate cancer and prostate model systems.

ABSTRACT: High secretion of the metabolites citrate and spermine is a unique hallmark for normal prostate epithelial cells, and is reduced in aggressive prostate cancer. However, the identity of the genes controlling this biological process is mostly unknown. In this study, we have created a gene signature of 150 genes connected to citrate and spermine secretion in the prostate. We have computationally integrated metabolic measurements with multiple transcriptomics datasets from the public domain, including 3826 tissue samples from prostate and prostate cancer. The accuracy of the signature is validated by its unique enrichment in prostate samples and prostate epithelial tissue compartments. The signature highlights genes AZGP1, ANPEP and metallothioneins with zinc-binding properties n

SUBMITTER: Rye MB 

PROVIDER: S-EPMC9189124 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature