CD73 promotes cervical cancer growth via EGFR/AKT1 pathway.

ABSTRACT:

Background

Cervical cancer ranks third in cancer incidence worldwide and is the most frequent gynecological cancer in developing countries. To expore the molecular mechanism of cervical cancer and to find effective treatment have become the focus of medical workers. CD73 has been implicated in the progression of many cancers. However, the study of CD73 in cervical cancer has not been reported. The aim of this study was to identify the effect and mechanism of CD73 overexpression on cervical cancer growth in vitro and in vivo.

Methods

Cervical cancer cell models with CD73 overexpression were construction by using lentiviruses infection in Hela and SiHa cells. Cell's proliferation was investigated by using xCELLigence real-time cell analysis (RTCA) system. Murine

SUBMITTER: Liu C 

PROVIDER: S-EPMC9189233 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature