DNA methylation patterns reflect individual's lifestyle independent of obesity.

ABSTRACT:

Objective

Obesity is driven by modifiable lifestyle factors whose effects may be mediated by epigenetics. Therefore, we investigated lifestyle effects on blood DNA methylation in participants of the LIFE-Adult study, a well-characterised population-based cohort from Germany.

Research design and methods

Lifestyle scores (LS) based on diet, physical activity, smoking and alcohol intake were calculated in 4107 participants of the LIFE-Adult study. Fifty subjects with an extremely healthy lifestyle and 50 with an extremely unhealthy lifestyle (5th and 95th percentiles LS) were selected for genome-wide DNA methylation analysis in blood samples employing Illumina Infinium® Methylation EPIC BeadChip system technology.

Results

Differences in DNA methylation patterns between b

SUBMITTER: Klemp I 

PROVIDER: S-EPMC9189420 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature