CircITCH suppresses cell proliferation and metastasis through miR-660/TFCP2 pathway in melanoma.

ABSTRACT:

Background

Melanoma is an aggressive disease that is rising in incidence. Advanced melanoma is still a life-threatening disease. CircRNAs are documented to be involved in melanoma progression. But circITCH role in melanoma remains unclear.

Methods and results

To explore the functions of circITCH in melanoma, levels of circITCH in melanoma tissues and paracarcinoma normal tissues were detected. To study the roles of circITCH in melanoma in terms of cell proliferation and migration, in vitro and in vivo experiments were performed. Mechanism study was designed to investigate the potential regulatory effect of circITCH in melanoma. Results revealed that circITCH expression was repressed in melanoma versus adjacent normal tissues. Function study showed that circITCH suppressed me

SUBMITTER: Zhang J 

PROVIDER: S-EPMC9189461 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature