Adiponectin and the risk of gastrointestinal cancers in East Asians: Mendelian randomization analysis.

ABSTRACT:

Background

Adiponectin is an important adipocytokine and has been associated with the risks of gastrointestinal cancers (GICs). Mendelian randomization (MR) analysis is needed to assess the causal relationships between adiponectin and GICs.

Methods

We retrieved the summary data of genome-wide association studies for adiponectin and six types of GICs in East Asians. A series of quality control steps were performed to select the eligible genetic instrumental tools. Horizontal pleiotropy and between-SNP heterogeneity were tested to choose the primary MR method. We also conducted sensitivity analyses to test the robustness of the main findings.

Results

We detected neither heterogeneity nor horizontal pleiotropy for the eligible SNPs in all of the MR analyses. Inverse vari

SUBMITTER: Jiang H 

PROVIDER: S-EPMC9189470 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature