The relevance of chromatin architecture to genome rearrangements in Drosophila.

ABSTRACT: DNA within chromosomes in the nucleus is non-randomly organized into chromosome territories, compartments and topologically associated domains (TADs). Chromosomal rearrangements have the potential to alter chromatin organization and modify gene expression leading to selection against these structural variants. Drosophila pseudoobscura has a wealth of naturally occurring gene arrangements that were generated by overlapping inversion mutations caused by two chromosomal breaks that rejoin the central region in reverse order. Unlike humans, Drosophila inversion heterozygotes do not have negative effects associated with crossing over during meiosis because males use achiasmate mechanisms for proper segregation, and aberrant recombinant meiotic products generated in females are los

SUBMITTER: Wright D 

PROVIDER: S-EPMC9189500 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature