Oxygen-Independent Sulfate Radical for Stimuli-Responsive Tumor Nanotherapy.

ABSTRACT: Variant modalities are quested and merged into the tumor nanotherapy by leveraging the excitation from external or intratumoral incentives. However, the ubiquitous hypoxia and the insufficient content of hydrogen peroxide (H₂ O₂ ) in tumor microenvironments inevitably hinder the effective production of reactive oxygen species (ROS). To radically extricate from the shackles, peroxymonosulfate (PMS: HSO₅ ^- )-loaded hollow mesoporous copper sulfide (CuS) nanoparticles (NPs) are prepared as the distinct ROS donors for sulfate radical (•SO₄ ^- )-mediated and stimuli-responsive tumor nanotherapy in an oxygen-independent manner. In this therapeutic modality, the second near-infrared laser irradiation, together with the released copp

SUBMITTER: Ding D 

PROVIDER: S-EPMC9189647 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature