A Revised Framework to Evaluate the Consistency Assumption Globally in a Network of Interventions.

ABSTRACT:

Background

The unrelated mean effects (UME) model has been proposed for evaluating the consistency assumption globally in the network of interventions. However, the UME model does not accommodate multiarm trials properly and omits comparisons between nonbaseline interventions in the multiarm trials not investigated in 2-arm trials.

Methods

We proposed a refinement of the UME model that tackles the limitations mentioned above. We also accompanied the scatterplots on the posterior mean deviance contributions of the trial arms under the network meta-analysis (NMA) and UME models with Bland-Altman plots to detect outlying trials contributing to poor model fit. We applied the refined and original UME models to 2 networks with multiarm trials.

Results

The original UME model

SUBMITTER: Spineli LM 

PROVIDER: S-EPMC9189723 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature