Genetics in Atopic Dermatitis: Historical Perspective and Future Prospects.

ABSTRACT: Atopic dermatitis (AD) is a common, complex trait, arising from the interplay of multiple genetic and environmental factors. This review provides an overview of developments in the field of AD genetics. AD shows high heritability; strategies to investigate genetic risk include linkage, candidate gene studies, genome-wide association and animal modelling. Loss-of-function mutations in FLG, encoding the skin barrier protein filaggrin, remain the strongest genetic risk factor identified for AD, but variants influencing skin and systemic immune function are also important. AD is at the forefront of genetic research, from large-scale population studies to in vitro models and detailed molecular analyses. An understanding of genetic risk factors has considerably improved knowledge of mechanisms l

SUBMITTER: Brown SJ 

PROVIDER: S-EPMC9189740 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature