Single-case disconnectome lesion-symptom mapping: Identifying two subtypes of limb apraxia.

ABSTRACT: Influential theories of skilled action posit that distinct cognitive mechanisms and neuroanatomic substrates support meaningless gesture imitation and tool use pantomiming, and poor performance on these tasks are hallmarks of limb apraxia. Yet prior research has primarily investigated brain-behavior relations at the group level; thus, it is unclear whether we can identify individuals with isolated impairments in meaningless gesture imitation or tool use pantomiming whose performance is associated with a distinct neuroanatomic lesion profile. The goal of this study was to test the hypothesis that individuals with disproportionately worse performance in meaningless gesture imitation would exhibit cortical damage and white matter disconnection in left fronto-parietal brain regions, whereas in

SUBMITTER: Metzgar R 

PROVIDER: S-EPMC9189785 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature