Osteoporosis is a novel risk factor of infections and sepsis: A cohort study.

ABSTRACT:

Background

Accumulating evidence suggests the interaction of bone metabolism and the immune system, but how bone health is associated with the risk of infections remains unknown.

Methods

This study aimed to investigate the relationship of bone mineral density (BMD) with the risk of common infections and sepsis in Hong Kong Osteoporosis Study (HKOS). A prospective cohort study, initiated in 1995 and followed until 31 December 2020, of 5,717 participants examined the association of BMD at three skeletal sites (lumbar spine, femoral neck, and total hip) with common infections - pneumonia, urinary tract infection (UTI), skin infection, and sepsis. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI).

Findings

During th

SUBMITTER: Zhang X 

PROVIDER: S-EPMC9189871 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature