Imaging-based indices of Neuropathology and gait speed decline in older adults: the atherosclerosis risk in communities study.

ABSTRACT: Imaging markers of cerebrovascular disease and Alzheimer's disease (AD) are implicated in mobility impairment in older adults, but few studies have examined these relationships longitudinally in a racially-diverse population-based sample. At Visit 5 (2011-13) of the ARIC Study, 1859 participants had usual pace gait speed (cm/s) assessed and brain MRI (mean age = 76.3, 28.5% Black) and PET (n = 343; mean age = 75.9, 42.6% Black) measures including total/regional brain volume (cm³), white matter hyperintensities (WMH; cm³), infarcts (present/absent), microbleeds (count) and global beta-amyloid (Aβ). Participants returned at Visit 6 (n = 1264, 2016-17) and Visit 7 (n = 1108, 2018-19) for follow-up gait speed assessments. We used linear regression to estimate effects of b

SUBMITTER: Sullivan KJ 

PROVIDER: S-EPMC9189901 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature