Reproductive factors and gall-bladder cancer, and the effect of common genetic variants on these associations: a case-control study in India.

ABSTRACT:

Background

In India, as elsewhere, the incidence of gall-bladder cancer (GBC) is substantially higher in women than in men. Yet, the relevance of reproductive factors to GBC remains poorly understood.

Methods

We used logistic regression adjusted for age, education and area to examine associations between reproductive factors and GBC risk, using 790 cases of histologically confirmed GBC and group-matched 1726 visitor controls. We tested the interaction of these associations by genetic variants known to increase the risk of GBC.

Results

Parity was strongly positively associated with GBC risk: each additional pregnancy was associated with an ∼25% higher risk {odds ratio [OR] 1.26 [95% confidence interval (95% CI) 1.17-1.37]}. After controlling for parity, GBC risk was we

SUBMITTER: Mhatre S 

PROVIDER: S-EPMC9189936 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature