Clinical polysomnographic methods for estimating pharyngeal collapsibility in obstructive sleep apnea.

ABSTRACT:

Study objectives

Obstructive sleep apnea has major health consequences but is challenging to treat. For many therapies, efficacy is determined by the severity of underlying pharyngeal collapsibility, yet there is no accepted clinical means to measure it. Here, we provide insight into which polysomnographic surrogate measures of collapsibility are valid, applicable across the population, and predictive of therapeutic outcomes.

Methods

Seven promising polysomnography-derived surrogate collapsibility candidates were evaluated: Vpassive (flow at eupneic ventilatory drive), Vmin (ventilation at nadir drive), event depth (depth of the average respiratory event), oxygen desaturation slope and mean oxygen desaturation (events-related averages), Fhypopneas (fraction of events scored

SUBMITTER: Vena D 

PROVIDER: S-EPMC9189952 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature