Estimating circadian phase in elementary school children: leveraging advances in physiologically informed models of circadian entrainment and wearable devices.

ABSTRACT:

Study objectives

Examine the ability of a physiologically based mathematical model of human circadian rhythms to predict circadian phase, as measured by salivary dim light melatonin onset (DLMO), in children compared to other proxy measurements of circadian phase (bedtime, sleep midpoint, and wake time).

Methods

As part of an ongoing clinical trial, a sample of 29 elementary school children (mean age: 7.4 ± .97 years) completed 7 days of wrist actigraphy before a lab visit to assess DLMO. Hourly salivary melatonin samples were collected under dim light conditions (<5 lx). Data from actigraphy were used to generate predictions of circadian phase using both a physiologically based circadian limit cycle oscillator mathematical model (Hannay model), and published regression equa

SUBMITTER: Moreno JP 

PROVIDER: S-EPMC9189953 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature