DNA methylation signatures reveal that distinct combinations of transcription factors specify human immune cell epigenetic identity.

ABSTRACT: Epigenetic reprogramming underlies specification of immune cell lineages, but patterns that uniquely define immune cell types and the mechanisms by which they are established remain unclear. Here, we identified lineage-specific DNA methylation signatures of six immune cell types from human peripheral blood and determined their relationship to other epigenetic and transcriptomic patterns. Sites of lineage-specific hypomethylation were associated with distinct combinations of transcription factors in each cell type. By contrast, sites of lineage-specific hypermethylation were restricted mostly to adaptive immune cells. PU.1 binding sites were associated with lineage-specific hypo- and hypermethylation in different cell types, suggesting that it regulates DNA methylation in a context-dependen

SUBMITTER: Roy R 

PROVIDER: S-EPMC9190145 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature