Development and validation of a novel mitophagy-related gene prognostic signature for glioblastoma multiforme.

ABSTRACT:

Background

Glioblastoma multiforme (GBM) is one of the most malignant tumors in brain with high morbidity and mortality. Mitophagy plays a significant role in carcinogenesis, metastasis, and invasion. In our study, we aim to construct a mitophagy-related risk model to predict prognosis in GBM.

Methods

RNA-seq data combined with clinical information were downloaded from TCGA. The 4-gene risk model and nomograph was then constructed and validated in external cohort. Evaluation of immune infiltration, functional enrichment and tumor microenvironment (TME) were then performed.

Result

A mitophagy-related risk model was established and patients in TCGA and CGGA were classified into low-risk and high-risk groups. In both cohorts, patients in low-risk group had improved survi

SUBMITTER: Wang J 

PROVIDER: S-EPMC9190154 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature