47XXY and 47XXX in Scleroderma and Myositis.

ABSTRACT:

Objective

We undertook this study to examine the X chromosome complement in participants with systemic sclerosis (SSc) as well as idiopathic inflammatory myopathies.

Methods

The participants met classification criteria for the diseases. All participants underwent single-nucleotide polymorphism typing. We examined X and Y single-nucleotide polymorphism heterogeneity to determine the number of X chromosomes. For statistical comparisons, we used χ² analyses with calculation of 95% confidence intervals.

Results

Three of seventy men with SSc had 47,XXY (P = 0.0001 compared with control men). Among the 435 women with SSc, none had 47,XXX. Among 709 men with polymyositis or dermatomyositis (PM/DM), seven had 47,XXY (P = 0.0016), whereas among the 1783 women with P

SUBMITTER: Scofield RH 

PROVIDER: S-EPMC9190224 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature