Redefining the Foreign Antigen and Self-Driven Memory CD4⁺ T-Cell Compartments via Transcriptomic, Phenotypic, and Functional Analyses.

ABSTRACT: Under steady-state conditions, conventional CD4⁺ T lymphocytes are classically divided into naïve (CD44^lo CD62L^hi) and memory (CD44^hi CD62L^lo) cell compartments. While the latter population is presumed to comprise a mixture of distinct subpopulations of explicit foreign antigen (Ag)-specific "authentic" memory and foreign Ag-independent memory-phenotype (MP) cells, phenotypic markers differentially expressed in these two cell types have yet to be identified. Moreover, while MP cells themselves have been previously described as heterogeneous, it is unknown whether they consist of distinct subsets defined by marker expression. In this study, we demonstrate using combined single-cell RNA sequencing and flow cytometric approaches that self

SUBMITTER: Kawabe T 

PROVIDER: S-EPMC9190281 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature