Association of CD209 (DC-SIGN) rs735240 SNV with paucibacillary leprosy in the Brazilian population and its functional effects.

ABSTRACT:

Background

Leprosy, caused by Mycobacterium leprae, is a public health problem in Brazil that affects peripheral nerves, resulting in physical disabilities. During host-pathogen interactions, the immune response determines leprosy outcomes from a localised (paucibacillary) form to a disseminated (multibacillary) form. The recognition of M. leprae involves the DC-SIGN receptor, which is present on the dendritic cells (DCs) and participates in immune activation.

Objectives

To evaluate the association of polymorphisms in the promoter region of the gene encoding DC-SIGN (CD209) and the clinical form of leprosy, and to investigate its functional effects.

Methods

The study population included 406 leprosy patients from an endemic area in Brazil [310 multibacillary (MB); 96 p

SUBMITTER: Germano GV 

PROVIDER: S-EPMC9190517 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature